"Understanding the Inherited Risk of Breast Cancer"
"How a Common PCSK9 Gene Variant Could Fuel Breast Cancer Spread and a Potential Antibody Solution" A widely inherited version of the PCSK9 gene, known for its role in cholesterol regulation, may also drive breast cancer cells to spread to other parts of the body (a process called metastasis). Excitingly, a lab-developed antibody already approved for managing cholesterol could hold promise in halting this cancer progression. A gene involved in setting cholesterol levels may also determine whether breast cancer spreads to other parts of the body. A variant of the PCSK9 gene drives the spread of breast cancer, but a lab-made antibody already approved to treat high cholesterol may help stop the exodus, researchers report December 9 in Cell . "For years, scientists have been on a detective hunt, meticulously examining normal tissues and breast cancers that had spread to other parts of the body. Their goal? To uncover the genetic 'smoking guns' the mutations within ...